Drug interactions
Clozapine + Miglitol
Severity: Moderate
Clozapine and Miglitol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine may cause hyperglycemia and insulin resistance, reducing the effectiveness of antidiabetic therapy such as miglitol. Glycemic control may worsen.
What this interaction means in plain words
Clozapine and Miglitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Miglitol belongs to Endocrine.
Why it happens
Clozapine-induced insulin resistance opposes the glucose-lowering effect of miglitol.
What to do
Monitor blood glucose and HbA1c more often and adjust the antidiabetic regimen. Reassess when clozapine is changed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Miglitol
- Miglitol + Pramlintide Major
- Aripiprazole + Miglitol Moderate
- Asenapine + Miglitol Moderate
- Chlorthalidone + Miglitol Moderate
- Cortisone + Miglitol Moderate
- Darunavir + Miglitol Moderate
Frequently asked questions
Can I take Clozapine with Miglitol?
MediHelp rates the interaction as moderate. Clozapine and Miglitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine may cause hyperglycemia and insulin resistance, reducing the effectiveness of antidiabetic therapy such as miglitol. Glycemic control may worsen.
How serious is the interaction between Clozapine and Miglitol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c more often and adjust the antidiabetic regimen. Reassess when clozapine is changed.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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