Drug interactions
Asenapine + Miglitol
Severity: Moderate
Asenapine and Miglitol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine may raise blood glucose and worsen glycemic control in patients treated with miglitol. Miglitol's modest glucose-lowering effect may be insufficient to offset it.
What this interaction means in plain words
Asenapine and Miglitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Miglitol belongs to Endocrine.
Why it happens
Antipsychotic-associated insulin resistance and metabolic effects oppose the effect of the alpha-glucosidase inhibitor; the exact mechanism is not fully established.
What to do
Monitor postprandial and fasting glucose and HbA1c after starting asenapine. Adjust or add antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Miglitol
- Miglitol + Pramlintide Major
- Aripiprazole + Miglitol Moderate
- Chlorthalidone + Miglitol Moderate
- Clozapine + Miglitol Moderate
- Cortisone + Miglitol Moderate
- Darunavir + Miglitol Moderate
Frequently asked questions
Can I take Asenapine with Miglitol?
MediHelp rates the interaction as moderate. Asenapine and Miglitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine may raise blood glucose and worsen glycemic control in patients treated with miglitol. Miglitol's modest glucose-lowering effect may be insufficient to offset it.
How serious is the interaction between Asenapine and Miglitol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor postprandial and fasting glucose and HbA1c after starting asenapine. Adjust or add antidiabetic therapy if control worsens.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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