Drug interactions
Insulin nph + Metolazone
Severity: Moderate
Insulin nph and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone can impair glucose tolerance and raise blood glucose, reducing the effect of insulin. Patients with diabetes may need higher insulin doses.
What this interaction means in plain words
Insulin nph and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazide-type diuretics reduce insulin secretion and sensitivity, partly via hypokalemia, opposing insulin's glucose-lowering action.
What to do
Monitor blood glucose when starting or stopping metolazone and adjust insulin dose as needed. Correct hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Frequently asked questions
Can I take Insulin nph with Metolazone?
MediHelp rates the interaction as moderate. Insulin nph and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone can impair glucose tolerance and raise blood glucose, reducing the effect of insulin. Patients with diabetes may need higher insulin doses.
How serious is the interaction between Insulin nph and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping metolazone and adjust insulin dose as needed. Correct hypokalemia.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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