Drug interactions
Iobenguane i + Modafinil
Severity: Moderate
Iobenguane i and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iobenguane is taken up by the norepinephrine transporter. Modafinil has some catecholamine reuptake effects, so it may in theory reduce uptake of the radiopharmaceutical and compromise imaging or therapy. Evidence is theoretical.
What this interaction means in plain words
Iobenguane i and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Modafinil may weakly inhibit the dopamine and norepinephrine transporters, theoretically competing with iobenguane uptake.
What to do
Hold modafinil for at least five half-lives before iobenguane dosing, and do not restart until the interval stated in the product labeling has passed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Frequently asked questions
Can I take Iobenguane i with Modafinil?
MediHelp rates the interaction as moderate. Iobenguane i and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iobenguane is taken up by the norepinephrine transporter. Modafinil has some catecholamine reuptake effects, so it may in theory reduce uptake of the radiopharmaceutical and compromise imaging or therapy. Evidence is theoretical.
How serious is the interaction between Iobenguane i and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold modafinil for at least five half-lives before iobenguane dosing, and do not restart until the interval stated in the product labeling has passed.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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