Drug interactions
Ioflupane i + Methamphetamine
Severity: Moderate
Ioflupane i and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ioflupane I-123 binds to the dopamine transporter for SPECT imaging, and drugs that bind this transporter with high affinity can interfere with the image. Methamphetamine acts at the dopamine transporter and may reduce tracer binding, causing misleading scans.
What this interaction means in plain words
Ioflupane i and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition at the dopamine transporter between methamphetamine and the radiotracer.
What to do
If clinically possible, withhold methamphetamine for an adequate interval before imaging in line with the product labeling. Otherwise interpret the scan cautiously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Ioflupane i with Methamphetamine?
MediHelp rates the interaction as moderate. Ioflupane i and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ioflupane I-123 binds to the dopamine transporter for SPECT imaging, and drugs that bind this transporter with high affinity can interfere with the image. Methamphetamine acts at the dopamine transporter and may reduce tracer binding, causing misleading scans.
How serious is the interaction between Ioflupane i and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If clinically possible, withhold methamphetamine for an adequate interval before imaging in line with the product labeling. Otherwise interpret the scan cautiously.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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