Drug interactions
Ipratropium-salbutamol + Lapatinib
Severity: Moderate
Ipratropium-salbutamol and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib can prolong the QT interval, and salbutamol may add risk through hypokalemia and tachycardia. At inhaled doses the added effect is generally small but may matter in patients with other risk factors. Torsades de pointes is the concern.
What this interaction means in plain words
Ipratropium-salbutamol and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Lapatinib belongs to Oncology.
Why it happens
Additive QT prolongation, with salbutamol-related hypokalemia contributing.
What to do
Correct potassium and magnesium before and during treatment and consider ECG monitoring in patients at risk. Limit salbutamol to the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Ipratropium-salbutamol with Lapatinib?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib can prolong the QT interval, and salbutamol may add risk through hypokalemia and tachycardia. At inhaled doses the added effect is generally small but may matter in patients with other risk factors. Torsades de pointes is the concern.
How serious is the interaction between Ipratropium-salbutamol and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before and during treatment and consider ECG monitoring in patients at risk. Limit salbutamol to the lowest effective dose.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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