Drug interactions
Ipratropium-salbutamol + Levofloxacin
Severity: Moderate
Ipratropium-salbutamol and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levofloxacin can prolong the QT interval, and salbutamol may contribute through hypokalemia and increased heart rate. Together they may increase the risk of torsades de pointes, especially in patients with heart disease, electrolyte abnormalities or other QT-prolonging drugs.
What this interaction means in plain words
Ipratropium-salbutamol and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Levofloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation, with beta-2 agonist-induced hypokalemia.
What to do
Correct potassium and magnesium deficits and obtain an ECG when other QT risk factors exist. Consider a non-QT-prolonging antibiotic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Ipratropium-salbutamol with Levofloxacin?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levofloxacin can prolong the QT interval, and salbutamol may contribute through hypokalemia and increased heart rate. Together they may increase the risk of torsades de pointes, especially in patients with heart disease, electrolyte abnormalities or other QT-prolonging drugs.
How serious is the interaction between Ipratropium-salbutamol and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium deficits and obtain an ECG when other QT risk factors exist. Consider a non-QT-prolonging antibiotic in high-risk patients.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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