Drug interactions
Ipratropium-salbutamol + Loxapine
Severity: Moderate
Ipratropium-salbutamol and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine has anticholinergic activity that may add to ipratropium, though systemic ipratropium exposure is low so this is usually minor. Inhaled loxapine can cause bronchospasm, and salbutamol is typically used to pretreat it. Loxapine may also cause QT prolongation and tachycardia that could add to salbutamol effects.
What this interaction means in plain words
Ipratropium-salbutamol and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Loxapine belongs to Central Nervous System.
Why it happens
Additive anticholinergic effects, with possible additive tachycardia and QT effects; inhaled loxapine causes bronchospasm countered by beta-agonists.
What to do
For inhaled loxapine, ensure a short-acting bronchodilator is available and screen for airway disease. Monitor for anticholinergic symptoms such as dry mouth, urinary retention and constipation, and for tachycardia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Ipratropium-salbutamol with Loxapine?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loxapine has anticholinergic activity that may add to ipratropium, though systemic ipratropium exposure is low so this is usually minor. Inhaled loxapine can cause bronchospasm, and salbutamol is typically used to pretreat it. Loxapine may also cause QT prolongation and tachycardia that could add to salbutamol effects.
How serious is the interaction between Ipratropium-salbutamol and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For inhaled loxapine, ensure a short-acting bronchodilator is available and screen for airway disease. Monitor for anticholinergic symptoms such as dry mouth, urinary retention and constipation, and for tachycardia.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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