Drug interactions
Ipratropium-salbutamol + Maprotiline
Severity: Moderate
Ipratropium-salbutamol and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline is a tetracyclic antidepressant that can potentiate the cardiovascular effects of salbutamol, including tachycardia, palpitations and blood pressure changes. Maprotiline also lowers the seizure threshold and can prolong the QT interval, which adds to the risk with high-dose beta-agonist use.
What this interaction means in plain words
Ipratropium-salbutamol and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Maprotiline belongs to Central Nervous System.
Why it happens
Noradrenaline reuptake inhibition and additive pharmacodynamic effects on cardiac adrenergic stimulation.
What to do
Monitor heart rate, blood pressure and ECG when salbutamol is used regularly or at high doses. Prefer standard inhaled doses and reassess the antidepressant if arrhythmia or palpitations occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Ipratropium-salbutamol with Maprotiline?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline is a tetracyclic antidepressant that can potentiate the cardiovascular effects of salbutamol, including tachycardia, palpitations and blood pressure changes. Maprotiline also lowers the seizure threshold and can prolong the QT interval, which adds to the risk with high-dose beta-agonist use.
How serious is the interaction between Ipratropium-salbutamol and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG when salbutamol is used regularly or at high doses. Prefer standard inhaled doses and reassess the antidepressant if arrhythmia or palpitations occur.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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