Drug interactions
Ipratropium-salbutamol + Mifepristone
Severity: Moderate
Ipratropium-salbutamol and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, so combining them may add to arrhythmia risk. The risk is greater with high-dose salbutamol, hypokalemia, or other QT-prolonging factors.
What this interaction means in plain words
Ipratropium-salbutamol and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Mifepristone belongs to Endocrine.
Why it happens
Additive QT interval prolongation; beta-agonist-induced hypokalemia may contribute.
What to do
Obtain an ECG and correct potassium and magnesium in patients with additional QT risk factors. Avoid frequent high-dose salbutamol during prolonged mifepristone therapy where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Ipratropium-salbutamol with Mifepristone?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation, so combining them may add to arrhythmia risk. The risk is greater with high-dose salbutamol, hypokalemia, or other QT-prolonging factors.
How serious is the interaction between Ipratropium-salbutamol and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and correct potassium and magnesium in patients with additional QT risk factors. Avoid frequent high-dose salbutamol during prolonged mifepristone therapy where possible.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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