Drug interactions
Ipratropium-salbutamol + Nadolol
Severity: Major
Ipratropium-salbutamol and Nadolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol is a non-selective beta-blocker that antagonises salbutamol and can cause severe bronchospasm in patients with asthma or COPD. It may render rescue bronchodilator therapy ineffective during an attack.
What this interaction means in plain words
Ipratropium-salbutamol and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ipratropium-salbutamol belongs to Respiratory; Nadolol belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism through blockade of beta-2 receptors by nadolol.
What to do
Avoid non-selective beta-blockers in patients with asthma and generally in significant reversible airway disease. If a beta-blocker is required, use a cardioselective agent with respiratory monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ipratropium-salbutamol
Other interactions of Nadolol
Frequently asked questions
Can I take Ipratropium-salbutamol with Nadolol?
MediHelp rates the interaction as major. Ipratropium-salbutamol and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nadolol is a non-selective beta-blocker that antagonises salbutamol and can cause severe bronchospasm in patients with asthma or COPD. It may render rescue bronchodilator therapy ineffective during an attack.
How serious is the interaction between Ipratropium-salbutamol and Nadolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid non-selective beta-blockers in patients with asthma and generally in significant reversible airway disease. If a beta-blocker is required, use a cardioselective agent with respiratory monitoring.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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