Drug interactions
Ipratropium-salbutamol + Pilocarpine
Severity: Minor
Ipratropium-salbutamol and Pilocarpine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pilocarpine stimulates muscarinic receptors while ipratropium blocks them, so they have opposing effects. Inhaled ipratropium has low systemic exposure, so the loss of effect is usually small, though local or ocular effects may differ.
What this interaction means in plain words
Ipratropium-salbutamol and Pilocarpine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ipratropium-salbutamol belongs to Respiratory; Pilocarpine belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
No routine adjustment is needed; watch for reduced pilocarpine effect such as persisting dry mouth.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ipratropium-salbutamol
Other interactions of Pilocarpine
- Amitriptyline + Pilocarpine Moderate
- Atenolol-chlorthalidone + Pilocarpine Moderate
- Atenolol + Pilocarpine Moderate
- Atropine + Pilocarpine Moderate
- Betaxolol + Pilocarpine Moderate
- Bethanechol + Pilocarpine Moderate
Frequently asked questions
Can I take Ipratropium-salbutamol with Pilocarpine?
MediHelp rates the interaction as minor. Ipratropium-salbutamol and Pilocarpine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pilocarpine stimulates muscarinic receptors while ipratropium blocks them, so they have opposing effects. Inhaled ipratropium has low systemic exposure, so the loss of effect is usually small, though local or ocular effects may differ.
How serious is the interaction between Ipratropium-salbutamol and Pilocarpine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for reduced pilocarpine effect such as persisting dry mouth.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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