Drug interactions
Ipratropium-salbutamol + Primaquine
Severity: Moderate
Ipratropium-salbutamol and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primaquine can prolong the QT interval and high-dose salbutamol may add to this by lowering potassium and increasing heart rate. Risk is mainly relevant in patients with other cardiac risk factors.
What this interaction means in plain words
Ipratropium-salbutamol and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Primaquine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia.
What to do
Check ECG and electrolytes in patients with cardiac risk factors and avoid excessive salbutamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Frequently asked questions
Can I take Ipratropium-salbutamol with Primaquine?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primaquine can prolong the QT interval and high-dose salbutamol may add to this by lowering potassium and increasing heart rate. Risk is mainly relevant in patients with other cardiac risk factors.
How serious is the interaction between Ipratropium-salbutamol and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes in patients with cardiac risk factors and avoid excessive salbutamol.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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