Drug interactions
Ipratropium-salbutamol + Tetrabenazine
Severity: Moderate
Ipratropium-salbutamol and Tetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both salbutamol (a beta-2 agonist) and tetrabenazine can prolong the QT interval, and beta-agonists may also cause hypokalemia and tachycardia. Combined use may increase the risk of ventricular arrhythmias, especially at high salbutamol doses or in patients with other risk factors.
What this interaction means in plain words
Ipratropium-salbutamol and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Tetrabenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation through pharmacodynamic effects, with beta-agonist-induced hypokalemia as a possible contributor.
What to do
Use the lowest effective salbutamol dose and obtain a baseline ECG in patients with cardiac risk factors. Monitor potassium and correct any deficit.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Tetrabenazine
- Dronedarone + Tetrabenazine Contraindicated
- Isocarboxazid + Tetrabenazine Contraindicated
- Linezolid + Tetrabenazine Contraindicated
- Phenelzine + Tetrabenazine Contraindicated
- Pimozide + Tetrabenazine Contraindicated
- Procarbazine + Tetrabenazine Contraindicated
Frequently asked questions
Can I take Ipratropium-salbutamol with Tetrabenazine?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both salbutamol (a beta-2 agonist) and tetrabenazine can prolong the QT interval, and beta-agonists may also cause hypokalemia and tachycardia. Combined use may increase the risk of ventricular arrhythmias, especially at high salbutamol doses or in patients with other risk factors.
How serious is the interaction between Ipratropium-salbutamol and Tetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective salbutamol dose and obtain a baseline ECG in patients with cardiac risk factors. Monitor potassium and correct any deficit.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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