Drug interactions
Ipratropium-salbutamol + Tiotropium
Severity: Moderate
Ipratropium-salbutamol and Tiotropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both ipratropium and tiotropium are inhaled antimuscarinic bronchodilators, so combining them duplicates therapy and may increase anticholinergic effects such as dry mouth, urinary retention and glaucoma risk. There is little added benefit from using both.
What this interaction means in plain words
Ipratropium-salbutamol and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Tiotropium belongs to Respiratory.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid scheduled use of both agents; stop ipratropium when tiotropium is used for maintenance and use salbutamol alone for rescue. Monitor for anticholinergic effects if both are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Tiotropium
Frequently asked questions
Can I take Ipratropium-salbutamol with Tiotropium?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both ipratropium and tiotropium are inhaled antimuscarinic bronchodilators, so combining them duplicates therapy and may increase anticholinergic effects such as dry mouth, urinary retention and glaucoma risk. There is little added benefit from using both.
How serious is the interaction between Ipratropium-salbutamol and Tiotropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid scheduled use of both agents; stop ipratropium when tiotropium is used for maintenance and use salbutamol alone for rescue. Monitor for anticholinergic effects if both are used.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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