Drug interactions
Ipratropium-salbutamol + Ziprasidone
Severity: Moderate
Ipratropium-salbutamol and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone prolongs the QT interval, and salbutamol can add to arrhythmia risk through hypokalemia and tachycardia. Ziprasidone also has mild anticholinergic activity, but the main concern is QT-related.
What this interaction means in plain words
Ipratropium-salbutamol and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation with beta2-agonist-induced hypokalemia and tachycardia.
What to do
Check potassium and magnesium and obtain an ECG in patients with cardiac disease or other QT-prolonging drugs; limit high-dose salbutamol where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Ipratropium-salbutamol with Ziprasidone?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziprasidone prolongs the QT interval, and salbutamol can add to arrhythmia risk through hypokalemia and tachycardia. Ziprasidone also has mild anticholinergic activity, but the main concern is QT-related.
How serious is the interaction between Ipratropium-salbutamol and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium and obtain an ECG in patients with cardiac disease or other QT-prolonging drugs; limit high-dose salbutamol where possible.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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