Drug interactions
Irbesartan + Ketoprofen
Severity: Moderate
Irbesartan and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can weaken the antihypertensive effect of angiotensin receptor blockers and, together, may cause acute kidney injury and hyperkalemia. Risk is greatest in older, dehydrated patients or those with existing renal impairment.
What this interaction means in plain words
Irbesartan and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Irbesartan belongs to Cardiovascular; Ketoprofen belongs to Musculoskeletal.
Why it happens
NSAID blockade of prostaglandin-mediated afferent arteriolar dilation combined with ARB efferent dilation reduces glomerular filtration and promotes sodium retention and potassium retention.
What to do
Monitor blood pressure, serum creatinine and potassium within the first weeks of combined use and keep the patient hydrated. Avoid the combination in volume depletion or advanced renal disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Irbesartan with Ketoprofen?
MediHelp rates the interaction as moderate. Irbesartan and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can weaken the antihypertensive effect of angiotensin receptor blockers and, together, may cause acute kidney injury and hyperkalemia. Risk is greatest in older, dehydrated patients or those with existing renal impairment.
How serious is the interaction between Irbesartan and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium within the first weeks of combined use and keep the patient hydrated. Avoid the combination in volume depletion or advanced renal disease.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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