Drug interactions
Irbesartan + Nadolol
Severity: Minor
Irbesartan and Nadolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers can modestly raise potassium by impairing cellular potassium uptake, and together with irbesartan this may add to hyperkalemia risk. Both lower blood pressure, so additive hypotension and bradycardia-related symptoms can occur. This combination is often used intentionally.
What this interaction means in plain words
Irbesartan and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Irbesartan belongs to Cardiovascular; Nadolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects, and reduced renin release and cellular potassium uptake from nonselective beta-blockade combined with reduced renal potassium excretion from the ARB.
What to do
Monitor blood pressure and heart rate, and check potassium periodically, especially with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Other interactions of Nadolol
Frequently asked questions
Can I take Irbesartan with Nadolol?
MediHelp rates the interaction as minor. Irbesartan and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Beta-blockers can modestly raise potassium by impairing cellular potassium uptake, and together with irbesartan this may add to hyperkalemia risk. Both lower blood pressure, so additive hypotension and bradycardia-related symptoms can occur. This combination is often used intentionally.
How serious is the interaction between Irbesartan and Nadolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and check potassium periodically, especially with renal impairment.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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