Drug interactions
Irbesartan + Tolfenamic acid
Severity: Moderate
Irbesartan and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as tolfenamic acid can reduce the antihypertensive effect of irbesartan and impair renal function. Together they raise the risk of acute kidney injury and hyperkalemia, particularly in older or volume-depleted patients.
What this interaction means in plain words
Irbesartan and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Irbesartan belongs to Cardiovascular; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and potassium excretion, compounding angiotensin receptor blockade.
What to do
Ensure adequate hydration and monitor blood pressure, serum creatinine and potassium. Use the lowest effective NSAID dose for the shortest time, or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Irbesartan and Tolfenamic acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Irbesartan with Tolfenamic acid?
MediHelp rates the interaction as moderate. Irbesartan and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as tolfenamic acid can reduce the antihypertensive effect of irbesartan and impair renal function. Together they raise the risk of acute kidney injury and hyperkalemia, particularly in older or volume-depleted patients.
How serious is the interaction between Irbesartan and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and monitor blood pressure, serum creatinine and potassium. Use the lowest effective NSAID dose for the shortest time, or choose an alternative analgesic.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
