Drug interactions
Irbesartan + Treprostinil
Severity: Moderate
Irbesartan and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a potent vasodilator, and combining it with irbesartan may produce additive blood pressure lowering. Symptomatic hypotension or dizziness can occur, especially during dose titration.
What this interaction means in plain words
Irbesartan and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Irbesartan belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Additive vasodilation and hypotensive effects through prostacyclin receptor agonism and angiotensin II receptor blockade.
What to do
Monitor blood pressure and symptoms of hypotension when starting or adjusting either drug. Reduce the antihypertensive dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Other interactions of Treprostinil
Frequently asked questions
Can I take Irbesartan with Treprostinil?
MediHelp rates the interaction as moderate. Irbesartan and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Treprostinil is a potent vasodilator, and combining it with irbesartan may produce additive blood pressure lowering. Symptomatic hypotension or dizziness can occur, especially during dose titration.
How serious is the interaction between Irbesartan and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension when starting or adjusting either drug. Reduce the antihypertensive dose if hypotension develops.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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