Drug interactions
Irinotecan + Ivacaftor
Severity: Minor
Irinotecan and Ivacaftor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor weakly inhibits P-gp and may modestly raise exposure to irinotecan, a P-gp substrate with a narrow therapeutic index. Increased toxicity such as diarrhea and neutropenia is theoretically possible. No clinical data exist for this pair.
What this interaction means in plain words
Irinotecan and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Irinotecan belongs to Oncology; Ivacaftor belongs to Miscellaneous.
Why it happens
Ivacaftor and its M1 metabolite weakly inhibit P-gp efflux.
What to do
Monitor for irinotecan toxicity, particularly diarrhea and neutropenia; no routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Irinotecan with Ivacaftor?
MediHelp rates the interaction as minor. Irinotecan and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor weakly inhibits P-gp and may modestly raise exposure to irinotecan, a P-gp substrate with a narrow therapeutic index. Increased toxicity such as diarrhea and neutropenia is theoretically possible. No clinical data exist for this pair.
How serious is the interaction between Irinotecan and Ivacaftor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for irinotecan toxicity, particularly diarrhea and neutropenia; no routine dose change is needed.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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