Drug interactions
Irinotecan + Lasmiditan
Severity: Minor
Irinotecan and Lasmiditan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-gp and BCRP in vitro, which could raise exposure to irinotecan and SN-38. Lasmiditan is used intermittently for migraine, so exposure is brief and clinical significance is uncertain.
What this interaction means in plain words
Irinotecan and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Irinotecan belongs to Oncology; Lasmiditan belongs to Central Nervous System.
Why it happens
Inhibition of intestinal P-gp and BCRP efflux transporters may increase absorption and reduce elimination of substrates.
What to do
Generally no action beyond awareness for single doses; monitor for diarrhoea and neutropenia if lasmiditan is used often around infusion days.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Irinotecan with Lasmiditan?
MediHelp rates the interaction as minor. Irinotecan and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits P-gp and BCRP in vitro, which could raise exposure to irinotecan and SN-38. Lasmiditan is used intermittently for migraine, so exposure is brief and clinical significance is uncertain.
How serious is the interaction between Irinotecan and Lasmiditan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Generally no action beyond awareness for single doses; monitor for diarrhoea and neutropenia if lasmiditan is used often around infusion days.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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