Drug interactions
Irinotecan + Osimertinib
Severity: Moderate
Irinotecan and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib inhibits BCRP in vitro and may increase exposure to SN-38, the active metabolite of irinotecan. This could increase gastrointestinal and hematologic toxicity.
What this interaction means in plain words
Irinotecan and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Irinotecan belongs to Oncology; Osimertinib belongs to Oncology.
Why it happens
Osimertinib inhibits BCRP-mediated efflux, which may reduce SN-38 elimination.
What to do
Monitor for diarrhea and neutropenia, and adjust the irinotecan dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Irinotecan and Osimertinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Osimertinib
Frequently asked questions
Can I take Irinotecan with Osimertinib?
MediHelp rates the interaction as moderate. Irinotecan and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib inhibits BCRP in vitro and may increase exposure to SN-38, the active metabolite of irinotecan. This could increase gastrointestinal and hematologic toxicity.
How serious is the interaction between Irinotecan and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diarrhea and neutropenia, and adjust the irinotecan dose if toxicity occurs.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
