Drug interactions
Irinotecan + Tafamidis
Severity: Minor
Irinotecan and Tafamidis: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tafamidis inhibits BCRP in vitro and could increase SN-38 exposure. The clinical effect is unproven and likely modest.
What this interaction means in plain words
Irinotecan and Tafamidis have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Irinotecan belongs to Oncology; Tafamidis belongs to Cardiovascular.
Why it happens
Tafamidis inhibits BCRP-mediated efflux.
What to do
Monitor for irinotecan toxicity such as diarrhea and neutropenia; routine dose change is not needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Tafamidis
- Apixaban + Tafamidis Moderate
- Atorvastatin + Tafamidis Moderate
- Methotrexate + Tafamidis Moderate
- Mitoxantrone + Tafamidis Moderate
- Pitavastatin + Tafamidis Moderate
- Rivaroxaban + Tafamidis Moderate
Frequently asked questions
Can I take Irinotecan with Tafamidis?
MediHelp rates the interaction as minor. Irinotecan and Tafamidis have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tafamidis inhibits BCRP in vitro and could increase SN-38 exposure. The clinical effect is unproven and likely modest.
How serious is the interaction between Irinotecan and Tafamidis?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for irinotecan toxicity such as diarrhea and neutropenia; routine dose change is not needed.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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