Drug interactions
Irinotecan liposomal + Ranolazine
Severity: Moderate
Irinotecan liposomal and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine inhibits P-gp, which may raise exposure to irinotecan and its active metabolite. This could increase diarrhea and myelosuppression, though clinical data are lacking.
What this interaction means in plain words
Irinotecan liposomal and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ranolazine inhibits P-glycoprotein efflux of irinotecan.
What to do
Monitor for diarrhea and neutropenia with blood counts. Consider alternatives to ranolazine if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Irinotecan liposomal with Ranolazine?
MediHelp rates the interaction as moderate. Irinotecan liposomal and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine inhibits P-gp, which may raise exposure to irinotecan and its active metabolite. This could increase diarrhea and myelosuppression, though clinical data are lacking.
How serious is the interaction between Irinotecan liposomal and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diarrhea and neutropenia with blood counts. Consider alternatives to ranolazine if toxicity emerges.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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