Drug interactions
Irinotecan liposomal + Zileuton
Severity: Minor
Irinotecan liposomal and Zileuton: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Irinotecan is activated by carboxylesterases and its active metabolite SN-38 is cleared by UGT1A1, while CYP3A4 forms inactive metabolites. Zileuton is a weak CYP3A4 inhibitor, and the effect on irinotecan exposure is uncertain and probably small. Irinotecan toxicities include severe diarrhea and neutropenia.
What this interaction means in plain words
Irinotecan liposomal and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by zileuton may alter irinotecan metabolism, though the clinical effect is not established.
What to do
No dose change is needed; monitor for diarrhea and neutropenia as routine during irinotecan therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Frequently asked questions
Can I take Irinotecan liposomal with Zileuton?
MediHelp rates the interaction as minor. Irinotecan liposomal and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Irinotecan is activated by carboxylesterases and its active metabolite SN-38 is cleared by UGT1A1, while CYP3A4 forms inactive metabolites. Zileuton is a weak CYP3A4 inhibitor, and the effect on irinotecan exposure is uncertain and probably small. Irinotecan toxicities include severe diarrhea and neutropenia.
How serious is the interaction between Irinotecan liposomal and Zileuton?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for diarrhea and neutropenia as routine during irinotecan therapy.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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