Drug interactions
Iron + Omadacycline
Severity: Moderate
Iron and Omadacycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral iron forms insoluble chelates with omadacycline in the gut, reducing its absorption. This can lower antibiotic exposure and risk treatment failure.
What this interaction means in plain words
Iron and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iron belongs to Gastrointestinal Tract; Omadacycline belongs to Anti Bacterial.
Why it happens
Chelation of the tetracycline by polyvalent iron cations in the gastrointestinal tract reduces absorption.
What to do
Give omadacycline at least 4 hours before or after oral iron preparations, as per labeling for multivalent cations. Alternatively, hold iron during the antibiotic course if clinically feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Iron
- Acetohydroxamic acid + Iron Moderate
- Aluminum hydroxide + Iron Moderate
- Baloxavir marboxil + Iron Moderate
- Calcium acetate + Iron Moderate
- Calcium carbonate + Iron Moderate
- Calcium citrate + Iron Moderate
Other interactions of Omadacycline
- Acitretin + Omadacycline Contraindicated
- Isotretinoin + Omadacycline Major
- Omadacycline + Tretinoin Major
- Aluminum hydroxide + Omadacycline Moderate
- Amoxicillin-clavulanic acid + Omadacycline Moderate
- Amoxicillin + Omadacycline Moderate
Frequently asked questions
Can I take Iron with Omadacycline?
MediHelp rates the interaction as moderate. Iron and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral iron forms insoluble chelates with omadacycline in the gut, reducing its absorption. This can lower antibiotic exposure and risk treatment failure.
How serious is the interaction between Iron and Omadacycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give omadacycline at least 4 hours before or after oral iron preparations, as per labeling for multivalent cations. Alternatively, hold iron during the antibiotic course if clinically feasible.
What other medicines interact with Iron?
MediHelp also lists interactions of Iron with, for example, Acetohydroxamic acid, Aluminum hydroxide, Baloxavir marboxil. The full list is on the Iron page.
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