Drug interactions
Iron + Omeprazole
Severity: Moderate
Iron and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omeprazole suppresses gastric acid, which lowers absorption of oral iron salts. Prolonged use has been linked to poorer iron stores and a reduced response to oral iron.
What this interaction means in plain words
Iron and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iron belongs to Gastrointestinal Tract; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Elevated gastric pH decreases iron solubility and reduction to absorbable ferrous iron.
What to do
Monitor hemoglobin and ferritin in patients on long-term PPI therapy taking oral iron. Consider a PPI dose reduction or intravenous iron if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Iron
- Acetohydroxamic acid + Iron Moderate
- Aluminum hydroxide + Iron Moderate
- Baloxavir marboxil + Iron Moderate
- Calcium acetate + Iron Moderate
- Calcium carbonate + Iron Moderate
- Calcium citrate + Iron Moderate
Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Frequently asked questions
Can I take Iron with Omeprazole?
MediHelp rates the interaction as moderate. Iron and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omeprazole suppresses gastric acid, which lowers absorption of oral iron salts. Prolonged use has been linked to poorer iron stores and a reduced response to oral iron.
How serious is the interaction between Iron and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and ferritin in patients on long-term PPI therapy taking oral iron. Consider a PPI dose reduction or intravenous iron if response is inadequate.
What other medicines interact with Iron?
MediHelp also lists interactions of Iron with, for example, Acetohydroxamic acid, Aluminum hydroxide, Baloxavir marboxil. The full list is on the Iron page.
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