Drug interactions
Magnesium + Roxadustat
Severity: Moderate
Magnesium and Roxadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium-containing products can bind roxadustat in the gut and reduce how much is absorbed. Lower exposure may blunt the haemoglobin response to treatment.
What this interaction means in plain words
Magnesium and Roxadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Magnesium belongs to Gastrointestinal Tract; Roxadustat belongs to Miscellaneous.
Why it happens
Chelation of roxadustat by multivalent cations in the gastrointestinal tract reduces its absorption.
What to do
Give roxadustat at least 1 hour after magnesium-containing products. Monitor haemoglobin and adjust roxadustat dose if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Roxadustat
- Gemfibrozil + Roxadustat Major
- Probenecid + Roxadustat Major
- Atorvastatin + Roxadustat Moderate
- Calcium acetate + Roxadustat Moderate
- Calcium + Roxadustat Moderate
- Iron + Roxadustat Moderate
Other interactions of Magnesium
- Ciprofloxacin + Magnesium Major
- Magnesium + Pancuronium Major
- Magnesium + Rocuronium Major
- Magnesium + Vecuronium Major
- Amikacin + Magnesium Moderate
- Amphotericin b deoxycholate + Magnesium Moderate
Frequently asked questions
Can I take Magnesium with Roxadustat?
MediHelp rates the interaction as moderate. Magnesium and Roxadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium-containing products can bind roxadustat in the gut and reduce how much is absorbed. Lower exposure may blunt the haemoglobin response to treatment.
How serious is the interaction between Magnesium and Roxadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give roxadustat at least 1 hour after magnesium-containing products. Monitor haemoglobin and adjust roxadustat dose if the response is inadequate.
What other medicines interact with Roxadustat?
MediHelp also lists interactions of Roxadustat with, for example, Gemfibrozil, Probenecid, Atorvastatin. The full list is on the Roxadustat page.
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