Drug interactions
Isavuconazole + Pioglitazone
Severity: Moderate
Isavuconazole and Pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pioglitazone is a weak CYP3A4 inducer and may modestly lower isavuconazole plasma concentrations. Reduced antifungal exposure could compromise treatment of invasive fungal infection.
What this interaction means in plain words
Isavuconazole and Pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isavuconazole belongs to Anti Fungals; Pioglitazone belongs to Endocrine.
Why it happens
Weak induction of CYP3A4/5 increases isavuconazole metabolism.
What to do
Monitor clinical response to antifungal therapy and consider isavuconazole trough levels where available. Use an alternative glucose-lowering agent if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isavuconazole
- Carbamazepine + Isavuconazole Contraindicated
- Efavirenz + Isavuconazole Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Isavuconazole + Ketoconazole Contraindicated
- Isavuconazole + Phenobarbitone Contraindicated
- Isavuconazole + Phenytoin Contraindicated
Other interactions of Pioglitazone
Frequently asked questions
Can I take Isavuconazole with Pioglitazone?
MediHelp rates the interaction as moderate. Isavuconazole and Pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pioglitazone is a weak CYP3A4 inducer and may modestly lower isavuconazole plasma concentrations. Reduced antifungal exposure could compromise treatment of invasive fungal infection.
How serious is the interaction between Isavuconazole and Pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to antifungal therapy and consider isavuconazole trough levels where available. Use an alternative glucose-lowering agent if response is inadequate.
What other medicines interact with Isavuconazole?
MediHelp also lists interactions of Isavuconazole with, for example, Carbamazepine, Efavirenz, Etravirine. The full list is on the Isavuconazole page.
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