Drug interactions
Isavuconazonium + Lapatinib
Severity: Moderate
Isavuconazonium and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a CYP3A4 substrate, and lapatinib is only a weak-to-moderate CYP3A4 inhibitor, so isavuconazole levels may rise slightly. Conversely, isavuconazole is itself a moderate CYP3A4 inhibitor and may raise lapatinib levels.
What this interaction means in plain words
Isavuconazonium and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isavuconazonium belongs to Anti Fungals; Lapatinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by each drug may reduce clearance of the other.
What to do
Monitor for lapatinib toxicity including QT prolongation and liver tests; consider lapatinib dose reduction if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Lapatinib?
MediHelp rates the interaction as moderate. Isavuconazonium and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole is a CYP3A4 substrate, and lapatinib is only a weak-to-moderate CYP3A4 inhibitor, so isavuconazole levels may rise slightly. Conversely, isavuconazole is itself a moderate CYP3A4 inhibitor and may raise lapatinib levels.
How serious is the interaction between Isavuconazonium and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lapatinib toxicity including QT prolongation and liver tests; consider lapatinib dose reduction if adverse effects occur.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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