Drug interactions
Isavuconazonium + Memantine-donepezil
Severity: Moderate
Isavuconazonium and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole inhibits CYP3A4 and OCT2, so it may raise levels of both donepezil and memantine. Increased donepezil exposure may heighten cholinergic effects such as bradycardia, while higher memantine levels may cause dizziness or confusion.
What this interaction means in plain words
Isavuconazonium and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isavuconazonium belongs to Anti Fungals; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Isavuconazole inhibits CYP3A4 (donepezil) and renal OCT2 transport (memantine).
What to do
Monitor heart rate, dizziness and cognition during co-administration. Reduce the dose of either component if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Memantine-donepezil?
MediHelp rates the interaction as moderate. Isavuconazonium and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole inhibits CYP3A4 and OCT2, so it may raise levels of both donepezil and memantine. Increased donepezil exposure may heighten cholinergic effects such as bradycardia, while higher memantine levels may cause dizziness or confusion.
How serious is the interaction between Isavuconazonium and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, dizziness and cognition during co-administration. Reduce the dose of either component if adverse effects appear.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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