Drug interactions
Isavuconazonium + Methoxsalen
Severity: Minor
Isavuconazonium and Methoxsalen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a CYP3A4 substrate, and methoxsalen may inhibit this enzyme and raise isavuconazole levels. The increase is likely small, with possible increased adverse effects.
What this interaction means in plain words
Isavuconazonium and Methoxsalen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isavuconazonium belongs to Anti Fungals; Methoxsalen belongs to Anti Fungals.
Why it happens
Possible weak CYP3A4 inhibition by methoxsalen.
What to do
No empiric dose change is required. Monitor for isavuconazole adverse effects such as liver enzyme elevation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Methoxsalen?
MediHelp rates the interaction as minor. Isavuconazonium and Methoxsalen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isavuconazole is a CYP3A4 substrate, and methoxsalen may inhibit this enzyme and raise isavuconazole levels. The increase is likely small, with possible increased adverse effects.
How serious is the interaction between Isavuconazonium and Methoxsalen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is required. Monitor for isavuconazole adverse effects such as liver enzyme elevation.
What other medicines interact with Methoxsalen?
MediHelp also lists interactions of Methoxsalen with, for example, Fezolinetant, Demeclocycline, Fedratinib. The full list is on the Methoxsalen page.
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