Drug interactions
Isavuconazonium + Mifepristone
Severity: Moderate
Isavuconazonium and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a CYP3A4 substrate, and mifepristone inhibits CYP3A4, so isavuconazole levels may rise. Isavuconazole may in turn inhibit mifepristone metabolism, raising exposure to both drugs.
What this interaction means in plain words
Isavuconazonium and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isavuconazonium belongs to Anti Fungals; Mifepristone belongs to Endocrine.
Why it happens
Mutual CYP3A4 inhibition: mifepristone reduces isavuconazole clearance and isavuconazole may raise mifepristone exposure.
What to do
Monitor for isavuconazole adverse effects such as liver enzyme elevation and QT shortening, and for mifepristone effects. Consider an alternative antifungal if mifepristone is used long term.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Mifepristone?
MediHelp rates the interaction as moderate. Isavuconazonium and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole is a CYP3A4 substrate, and mifepristone inhibits CYP3A4, so isavuconazole levels may rise. Isavuconazole may in turn inhibit mifepristone metabolism, raising exposure to both drugs.
How serious is the interaction between Isavuconazonium and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for isavuconazole adverse effects such as liver enzyme elevation and QT shortening, and for mifepristone effects. Consider an alternative antifungal if mifepristone is used long term.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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