Drug interactions
Isavuconazonium + Pramipexole
Severity: Minor
Isavuconazonium and Pramipexole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole inhibits OCT2 and may reduce renal secretion of pramipexole, raising its levels. The effect is likely modest but could amplify dopaminergic adverse effects.
What this interaction means in plain words
Isavuconazonium and Pramipexole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isavuconazonium belongs to Anti Fungals; Pramipexole belongs to Cardiovascular.
Why it happens
Isavuconazole inhibits renal OCT2-mediated tubular secretion of pramipexole.
What to do
Monitor for somnolence, nausea, dyskinesia and orthostatic hypotension, and lower the pramipexole dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Isavuconazonium and Pramipexole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Pramipexole
- Amisulpride + Pramipexole Contraindicated
- Chlorpromazine + Pramipexole Major
- Droperidol + Pramipexole Major
- Fluphenazine + Pramipexole Major
- Haloperidol + Pramipexole Major
- Iloperidone + Pramipexole Major
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Pramipexole?
MediHelp rates the interaction as minor. Isavuconazonium and Pramipexole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isavuconazole inhibits OCT2 and may reduce renal secretion of pramipexole, raising its levels. The effect is likely modest but could amplify dopaminergic adverse effects.
How serious is the interaction between Isavuconazonium and Pramipexole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for somnolence, nausea, dyskinesia and orthostatic hypotension, and lower the pramipexole dose if they occur.
What other medicines interact with Pramipexole?
MediHelp also lists interactions of Pramipexole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Pramipexole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
