Drug interactions
Isavuconazonium + Prednisone
Severity: Moderate
Isavuconazonium and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a moderate CYP3A4 inhibitor and may raise prednisolone exposure modestly, while steroid-related immunosuppression adds to infection risk in patients treated for invasive fungal disease. Reduced isavuconazole exposure from prednisone is not well supported.
What this interaction means in plain words
Isavuconazonium and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isavuconazonium belongs to Anti Fungals; Prednisone belongs to Endocrine.
Why it happens
CYP3A4 inhibition by isavuconazole may reduce prednisolone clearance, and steroids add pharmacodynamic immunosuppression.
What to do
Monitor for corticosteroid adverse effects and for response of the fungal infection. Use the lowest effective prednisone dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Prednisone?
MediHelp rates the interaction as moderate. Isavuconazonium and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole is a moderate CYP3A4 inhibitor and may raise prednisolone exposure modestly, while steroid-related immunosuppression adds to infection risk in patients treated for invasive fungal disease. Reduced isavuconazole exposure from prednisone is not well supported.
How serious is the interaction between Isavuconazonium and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid adverse effects and for response of the fungal infection. Use the lowest effective prednisone dose.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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