Drug interactions
Isavuconazonium + Quinidine
Severity: Moderate
Isavuconazonium and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a moderate CYP3A4 inhibitor and a P-gp inhibitor and may raise quinidine concentrations. Isavuconazole shortens the QT interval, which could oppose quinidine's effect, but the elevated quinidine exposure still carries arrhythmia risk. Quinidine may modestly raise isavuconazole levels.
What this interaction means in plain words
Isavuconazonium and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isavuconazonium belongs to Anti Fungals; Quinidine belongs to Anti Parasitic.
Why it happens
Isavuconazole inhibits CYP3A4 and P-glycoprotein, reducing quinidine clearance.
What to do
Monitor quinidine levels and ECG, and reduce the quinidine dose if levels or QTc rise. Watch for isavuconazole adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Quinidine?
MediHelp rates the interaction as moderate. Isavuconazonium and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole is a moderate CYP3A4 inhibitor and a P-gp inhibitor and may raise quinidine concentrations. Isavuconazole shortens the QT interval, which could oppose quinidine's effect, but the elevated quinidine exposure still carries arrhythmia risk. Quinidine may modestly raise isavuconazole levels.
How serious is the interaction between Isavuconazonium and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor quinidine levels and ECG, and reduce the quinidine dose if levels or QTc rise. Watch for isavuconazole adverse effects.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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