Drug interactions
Isavuconazonium + Rifampicin
Severity: Contraindicated
Isavuconazonium and Rifampicin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin strongly induces CYP3A4 and dramatically lowers isavuconazole exposure after isavuconazonium administration. This risks failure of therapy for invasive fungal infection.
What this interaction means in plain words
Isavuconazonium and Rifampicin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isavuconazonium belongs to Anti Fungals; Rifampicin belongs to Anti Bacterial.
Why it happens
Potent induction of CYP3A4/5 by rifampicin increases isavuconazole clearance.
What to do
Do not coadminister; use an alternative antimycobacterial agent or antifungal.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Rifampicin?
MediHelp rates the interaction as contraindicated. Isavuconazonium and Rifampicin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rifampicin strongly induces CYP3A4 and dramatically lowers isavuconazole exposure after isavuconazonium administration. This risks failure of therapy for invasive fungal infection.
How serious is the interaction between Isavuconazonium and Rifampicin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative antimycobacterial agent or antifungal.
What other medicines interact with Isavuconazonium?
MediHelp also lists interactions of Isavuconazonium with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Isavuconazonium page.
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