Drug interactions
Isavuconazonium + Sertraline
Severity: Minor
Isavuconazonium and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a CYP3A4 substrate and moderate inhibitor, whereas sertraline is at most a weak CYP3A4 inhibitor. Any effect of sertraline on isavuconazole is expected to be small, while isavuconazole might raise sertraline levels.
What this interaction means in plain words
Isavuconazonium and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isavuconazonium belongs to Anti Fungals; Sertraline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by sertraline; isavuconazole may itself modestly inhibit sertraline metabolism.
What to do
No dose change is routinely needed; monitor for sertraline adverse effects and antifungal tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Sertraline?
MediHelp rates the interaction as minor. Isavuconazonium and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isavuconazole is a CYP3A4 substrate and moderate inhibitor, whereas sertraline is at most a weak CYP3A4 inhibitor. Any effect of sertraline on isavuconazole is expected to be small, while isavuconazole might raise sertraline levels.
How serious is the interaction between Isavuconazonium and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor for sertraline adverse effects and antifungal tolerability.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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