Drug interactions
Isavuconazonium + Verapamil
Severity: Moderate
Isavuconazonium and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole, the active moiety, is a CYP3A4 substrate, and verapamil as a moderate CYP3A4 inhibitor may increase its levels. Isavuconazole itself is a moderate CYP3A4 inhibitor and could raise verapamil levels. The result may be higher exposure of both drugs.
What this interaction means in plain words
Isavuconazonium and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isavuconazonium belongs to Anti Fungals; Verapamil belongs to Cardiovascular.
Why it happens
Bidirectional CYP3A4 inhibition.
What to do
Monitor blood pressure, heart rate and ECG, and watch for isavuconazole adverse effects such as hepatic enzyme elevation. Reduce the verapamil dose if hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Verapamil?
MediHelp rates the interaction as moderate. Isavuconazonium and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole, the active moiety, is a CYP3A4 substrate, and verapamil as a moderate CYP3A4 inhibitor may increase its levels. Isavuconazole itself is a moderate CYP3A4 inhibitor and could raise verapamil levels. The result may be higher exposure of both drugs.
How serious is the interaction between Isavuconazonium and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG, and watch for isavuconazole adverse effects such as hepatic enzyme elevation. Reduce the verapamil dose if hypotension or bradycardia occurs.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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