Drug interactions
Isavuconazonium + Ziprasidone
Severity: Moderate
Isavuconazonium and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a moderate CYP3A4 inhibitor, and ziprasidone is partly metabolized by CYP3A4, so ziprasidone exposure may rise. Azole antifungals can also prolong the QT interval, though isavuconazole tends to shorten it. The legacy direction is reversed: ziprasidone does not meaningfully affect isavuconazole.
What this interaction means in plain words
Isavuconazonium and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isavuconazonium belongs to Anti Fungals; Ziprasidone belongs to Central Nervous System.
Why it happens
Isavuconazole inhibits CYP3A4, which may modestly raise ziprasidone concentrations.
What to do
Monitor ECG and electrolytes and watch for ziprasidone adverse effects such as sedation and QT prolongation. Reduce the ziprasidone dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Ziprasidone?
MediHelp rates the interaction as moderate. Isavuconazonium and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole is a moderate CYP3A4 inhibitor, and ziprasidone is partly metabolized by CYP3A4, so ziprasidone exposure may rise. Azole antifungals can also prolong the QT interval, though isavuconazole tends to shorten it. The legacy direction is reversed: ziprasidone does not meaningfully affect isavuconazole.
How serious is the interaction between Isavuconazonium and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes and watch for ziprasidone adverse effects such as sedation and QT prolongation. Reduce the ziprasidone dose if needed.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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