Drug interactions
Isocarboxazid + Lasmiditan
Severity: Moderate
Isocarboxazid and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan is a 5-HT1F agonist that causes sedation and dizziness, which may be additive with the CNS effects of an MAO inhibitor. A theoretical risk of serotonin toxicity also exists because of the MAO inhibitor's raised serotonin levels, although lasmiditan lacks vasoconstrictive 5-HT1B/1D activity.
What this interaction means in plain words
Isocarboxazid and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isocarboxazid belongs to Central Nervous System; Lasmiditan belongs to Central Nervous System.
Why it happens
Additive CNS depression plus theoretical serotonergic excess from MAO inhibition.
What to do
Counsel the patient about sedation and advise against driving for at least 8 hours after a lasmiditan dose. Monitor for signs of serotonin syndrome such as agitation, tremor, hyperthermia and clonus.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Isocarboxazid with Lasmiditan?
MediHelp rates the interaction as moderate. Isocarboxazid and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan is a 5-HT1F agonist that causes sedation and dizziness, which may be additive with the CNS effects of an MAO inhibitor. A theoretical risk of serotonin toxicity also exists because of the MAO inhibitor's raised serotonin levels, although lasmiditan lacks vasoconstrictive 5-HT1B/1D activity.
How serious is the interaction between Isocarboxazid and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about sedation and advise against driving for at least 8 hours after a lasmiditan dose. Monitor for signs of serotonin syndrome such as agitation, tremor, hyperthermia and clonus.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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