Drug interactions
Isocarboxazid + Lurasidone
Severity: Moderate
Isocarboxazid and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an MAOI with lurasidone may cause additive hypotension and sedation, and in rare cases serotonergic or neuroleptic malignant syndrome-like reactions. Orthostatic hypotension and falls are the main practical concerns.
What this interaction means in plain words
Isocarboxazid and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isocarboxazid belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects: alpha-adrenergic blockade and CNS depression from lurasidone combined with the hypotensive and CNS effects of MAOI therapy.
What to do
Monitor blood pressure, especially orthostatic readings, and sedation when starting or adjusting either drug. Watch for fever, rigidity or mental status change and adjust doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Isocarboxazid with Lurasidone?
MediHelp rates the interaction as moderate. Isocarboxazid and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an MAOI with lurasidone may cause additive hypotension and sedation, and in rare cases serotonergic or neuroleptic malignant syndrome-like reactions. Orthostatic hypotension and falls are the main practical concerns.
How serious is the interaction between Isocarboxazid and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, especially orthostatic readings, and sedation when starting or adjusting either drug. Watch for fever, rigidity or mental status change and adjust doses as needed.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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