Drug interactions
Isoflurane + Itraconazole
Severity: Moderate
Isoflurane and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so combining them could add to arrhythmia risk during anesthesia. Evidence is limited and largely theoretical.
What this interaction means in plain words
Isoflurane and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Itraconazole belongs to Anti Fungals.
Why it happens
Additive effects on cardiac repolarization.
What to do
Check the baseline QTc and correct electrolytes before surgery. Monitor the ECG intraoperatively in patients with other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Isoflurane
Frequently asked questions
Can I take Isoflurane with Itraconazole?
MediHelp rates the interaction as moderate. Isoflurane and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, so combining them could add to arrhythmia risk during anesthesia. Evidence is limited and largely theoretical.
How serious is the interaction between Isoflurane and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the baseline QTc and correct electrolytes before surgery. Monitor the ECG intraoperatively in patients with other risk factors.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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