Drug interactions
Isoflurane + Macimorelin
Severity: Moderate
Isoflurane and Macimorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin can prolong the QT interval and is used as a single-dose diagnostic test, so overlap with isoflurane anesthesia is unlikely. If combined, additive QT prolongation is possible.
What this interaction means in plain words
Isoflurane and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Macimorelin belongs to Endocrine.
Why it happens
Additive effects on cardiac repolarization.
What to do
Do not schedule macimorelin testing around general anesthesia. If both are needed, separate them by several half-lives of macimorelin and check the ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoflurane
Other interactions of Macimorelin
Frequently asked questions
Can I take Isoflurane with Macimorelin?
MediHelp rates the interaction as moderate. Isoflurane and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin can prolong the QT interval and is used as a single-dose diagnostic test, so overlap with isoflurane anesthesia is unlikely. If combined, additive QT prolongation is possible.
How serious is the interaction between Isoflurane and Macimorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not schedule macimorelin testing around general anesthesia. If both are needed, separate them by several half-lives of macimorelin and check the ECG.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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