Drug interactions
Isoflurane + Moxifloxacin
Severity: Moderate
Isoflurane and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoflurane can prolong the QT interval and moxifloxacin has the same effect, so perioperative use together may raise the risk of torsades de pointes. Anesthetic conditions such as electrolyte shifts and sympathetic stimulation may add to the risk.
What this interaction means in plain words
Isoflurane and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive prolongation of ventricular repolarization through potassium channel effects.
What to do
Review the preoperative ECG and correct potassium and magnesium before anesthesia. Monitor the ECG during and after surgery in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Isoflurane
Frequently asked questions
Can I take Isoflurane with Moxifloxacin?
MediHelp rates the interaction as moderate. Isoflurane and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoflurane can prolong the QT interval and moxifloxacin has the same effect, so perioperative use together may raise the risk of torsades de pointes. Anesthetic conditions such as electrolyte shifts and sympathetic stimulation may add to the risk.
How serious is the interaction between Isoflurane and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the preoperative ECG and correct potassium and magnesium before anesthesia. Monitor the ECG during and after surgery in patients with other QT risk factors.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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