Drug interactions
Isoflurane + Osilodrostat
Severity: Moderate
Isoflurane and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osilodrostat prolongs the QT interval, and isoflurane has a similar effect. Together they may increase the risk of torsades de pointes, particularly with hypokalemia, which osilodrostat can also cause.
What this interaction means in plain words
Isoflurane and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Osilodrostat belongs to Endocrine.
Why it happens
Additive QT prolongation.
What to do
Correct potassium and magnesium before surgery and monitor ECG perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoflurane
Other interactions of Osilodrostat
Frequently asked questions
Can I take Isoflurane with Osilodrostat?
MediHelp rates the interaction as moderate. Isoflurane and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osilodrostat prolongs the QT interval, and isoflurane has a similar effect. Together they may increase the risk of torsades de pointes, particularly with hypokalemia, which osilodrostat can also cause.
How serious is the interaction between Isoflurane and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before surgery and monitor ECG perioperatively.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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