Drug interactions
Isoflurane + Osimertinib
Severity: Moderate
Isoflurane and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib can prolong the QT interval, and isoflurane has similar effects. The combination may increase the chance of torsades de pointes, particularly with electrolyte abnormalities.
What this interaction means in plain words
Isoflurane and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Osimertinib belongs to Oncology.
Why it happens
Additive prolongation of ventricular repolarization (QTc).
What to do
Review a baseline ECG and correct potassium and magnesium before surgery. Monitor the ECG during anesthesia and recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoflurane
Other interactions of Osimertinib
Frequently asked questions
Can I take Isoflurane with Osimertinib?
MediHelp rates the interaction as moderate. Isoflurane and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib can prolong the QT interval, and isoflurane has similar effects. The combination may increase the chance of torsades de pointes, particularly with electrolyte abnormalities.
How serious is the interaction between Isoflurane and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review a baseline ECG and correct potassium and magnesium before surgery. Monitor the ECG during anesthesia and recovery.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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