Drug interactions
Isoflurane + Perphenazine
Severity: Moderate
Isoflurane and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoflurane can prolong the QT interval and perphenazine has similar potential, so the combination may increase the risk of ventricular arrhythmias during anesthesia. Additive hypotension and CNS depression may also occur.
What this interaction means in plain words
Isoflurane and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Additive QTc prolongation and additive CNS and cardiovascular depression.
What to do
Inform the anesthesia team of perphenazine use and review the preoperative ECG and electrolytes. Monitor ECG and blood pressure continuously during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Isoflurane
Frequently asked questions
Can I take Isoflurane with Perphenazine?
MediHelp rates the interaction as moderate. Isoflurane and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoflurane can prolong the QT interval and perphenazine has similar potential, so the combination may increase the risk of ventricular arrhythmias during anesthesia. Additive hypotension and CNS depression may also occur.
How serious is the interaction between Isoflurane and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of perphenazine use and review the preoperative ECG and electrolytes. Monitor ECG and blood pressure continuously during anesthesia.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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