Drug interactions
Isoflurane + Rilpivirine
Severity: Moderate
Isoflurane and Rilpivirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilpivirine can prolong the QT interval at supratherapeutic doses, and isoflurane can also lengthen the QT interval. At standard doses the combined risk is small but may matter with other QT risk factors.
What this interaction means in plain words
Isoflurane and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Rilpivirine belongs to Anti Virals.
Why it happens
Additive prolongation of ventricular repolarization (QTc).
What to do
Check a baseline ECG and electrolytes in patients with other QT risk factors. Monitor the ECG during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoflurane
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Isoflurane with Rilpivirine?
MediHelp rates the interaction as moderate. Isoflurane and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rilpivirine can prolong the QT interval at supratherapeutic doses, and isoflurane can also lengthen the QT interval. At standard doses the combined risk is small but may matter with other QT risk factors.
How serious is the interaction between Isoflurane and Rilpivirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes in patients with other QT risk factors. Monitor the ECG during anesthesia.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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